Sodium Hydroxide → HCID 19387387, compound

Participants

Reaction Steps

Methyl-2-(2-amino-4-trifluoromethylphenoxy)-4-methoxybenzoate (13.0 g, 0.038 mol) was mixed in tetrahydrofuran and saponified with 1N sodium hydroxide. The solvent was evaporated and the residue mixed in water and acidified with 3N hydrochloric acid, bringing the pH to 4.0. The aqueous phase was extracted with ethyl acetate. The organic phase was dried (MgSO4) and evaporated. The residue was flash chromatographed (silica gel, ethyl acetate/hexane/formic acid) to yield the title compound. 1H NMR (250 MHz, methanol d) δ8.00 (d, 1H), 7.10 (d, 1H), 6.88 (dd, 1H), 6.73-6.81 (m, 2H), 6.45 (d, 1H), 3.79 (s, 3H).

Provenance & Evidence