Dichloromethane → HCID 54569902, compound

Participants

Reaction Conditions

Reaction Steps

m-Chloroperbenzoic acid (50% grade, 1.38 g, 4.01 mmol) was added in portions to a vigorously stirred mixture of 8-(2,4-dichlorophenyl)-1-octene (687 mg, 2.67 mmol), saturated aqueous NaHCO3 (15 ml), and dichloromethane (10 ml) at 0° C. The mixture was stirred for 5 min at 0° C., at room temperature for 1 h, then poured into water, and extracted with ether. The extracts were washed with aqueous Na2SO3 /NaHCO3, water, saturated aqueous NaCl, and dried (MgSO4). The solvent was removed under vacuum and the residue purified by chromatography on silica gel (5-20% ether/petroleum ether 40°-60° C.) to give the title compound (265 mg, 25%, 3 steps) as an oil.

Provenance & Evidence