Methanol → HCID 23177148, compound

HRID 2399346Notes

Reaction equation

HRID 2399346 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([OH:9])=[CH:4][C:3]=1[CH2:10][C:11]([OH:13])=[O:12].[CH3:14]O>>[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[C:5]([OH:9])=[CH:4][C:3]=1[CH2:10][C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 887MethanolHCID 20569249HCID 20569249, compound

Product 1

HCID 23177148HCID 23177148, compound

Procedure

A mixture of 145.6 g of 2,5-dihydroxy-4-methylphenylacetic acid and 45 g of dry sulfonic acid resin (IRN-77R) is heated under reflux in 4.38 liters of absolute methanol. The mixture is filtered and the filtrate evaporated. The white solid is recrystallized from a mixture of ethyl acetate and heptane (50:50), yielding white crystals with the following characteristics:

Workup

  1. temperatureis heated
  2. filtrationThe mixture is filtered
  3. customthe filtrate evaporated
  4. customThe white solid is recrystallized from a mixture of ethyl acetate and heptane (50:50)
  5. customyielding white crystals with the following characteristics

Sources & evidence

ORD record
ord-7c594939551e45498c67353559fe1980
Source dataset
uspto-grants-1995_09
Patent number
US05449518

Reaction notes

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