Ammonia → HCID 19385477, compound

HRID 2399353Notes

Reaction equation

HRID 2399353 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH:9]=2)=[CH:6][CH:7]=1.O.[NH3:22]>C(Cl)(Cl)Cl>[NH2:22][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])[CH:9]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 193854813-Chloro-6-[4-methoxy-3-(2-methylpropoxy)phenyl]pyridazine

Product 1

HCID 19385477HCID 19385477, compoundYield 53.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

7.0 g (24 mmol) of 3-chloro-6-[4-methoxy-3-(2-methylpropoxy)phenyl]pyridazine are reacted as described in Example 1 in 40 ml of ammonia-saturated ethylene glycol. The crude product obtained by precipitation with water is dissolved in chloroform, the solution is dried with potassium carbonate, and the product is precipitated with petroleum ether (b.p. 50°-70° C.). 3.5 g (53.8%) of the title compound of m.p. 187° C. are obtained.

Workup

  1. dry with materialthe solution is dried with potassium carbonate
  2. customthe product is precipitated with petroleum ether (b.p. 50°-70° C.)

Sources & evidence

ORD record
ord-29bcd886e71443b4bfad3506a3ca3f7a
Source dataset
uspto-grants-1995_09
Patent number
US05449676

Reaction notes

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