反应详情

14 g (46 mmol) of 3-chloro-6-(3-cyclopentyloxy-4-methoxyphenyl)pyridazine are heated in 74 g (0.69 mol) of benzylamine at 200° C. for 3 hours. The mixture is subsequently poured onto ice and extracted with dichloromethane, and the organic phase is dried with potassium carbonate and then concentrated. Petroleum ether (b.p. 50°-70° C.) is added to the residue, and the resulting precipitate is filtered off with suction and crystallized from ethyl acetate/cyclohexane. 15.9 g (92.4%) of 3-benzylamino-6-(3-cyclopentyloxy-4-methoxyphenyl)pyridazine of m.p. 116° C. are obtained.

1. additionThe mixture is subsequently poured onto ice
2. extractionextracted with dichloromethane
3. dry with materialthe organic phase is dried with potassium carbonate
4. concentrationconcentrated
5. additionPetroleum ether (b.p. 50°-70° C.) is added to the residue
6. filtrationthe resulting precipitate is filtered off with suction
7. customcrystallized from ethyl acetate/cyclohexane