Hydrogen Peroxide → HCID 178487484, compound

Participants

Reaction Steps

20.0 g (74.8 mmol) of 3-amino-6-(4-difluoromethoxy-3-methoxyphenyl)pyridazine are dissolved in 100 ml of glacial acetic acid and, while stirring, 30.6 ml (300 mmol) of 30% strength hydrogen peroxide are added, and the mixture is stirred at 80° C. for 2.5 h. The reaction solution is diluted with 1 kg of ice and 200 ml of concentrated ammonia solution, and the precipitate which has formed is collected on a suction funnel, washed first with water and then with ethanol and petroleum ether (b.p. 40°-70° C.) and dried at 75° C. in vacuo. 18.1 g (85.4%) of the title compound of m.p. 214° C. are obtained.

Provenance & Evidence