HCID 22855968, compound → HCID 10621099, compound

Participants

Reaction Steps

To a solution of (2R,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-[(E)-2-ethoxycarbonylvinyl]-pyrrolidine (20 g, 50 mmol) in ethanol (500 ml) was added 10% palladium-carbon (5 g), and the mixture was stirred under atmospheric pressure in a hydrogen atmosphere at room temperature for 2 h. Further, 10% palladium-carbon (2 g) was added thereto, and the mixture was stirred under atmospheric pressure in a hydrogen atmosphere at room temperature for 1.5 h. The catalyst was filtered off, and the solvent was removed in vacuo. The residue was subjected to silica gel column chromatography (Wakogel™ C-300, heptane-ethyl acetate) to give (2R,4R)-N-tert-butoxycarbonyl-4-tert-butyldimethylsiloxy-2-(2-ethoxycarbonylethyl)pyrrolidine (15.62 g, yield: 78%).

Provenance & Evidence