HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl 2-(4-formyl-2-methylphenoxy)phenylacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | 4-Hydroxy-3-methylbenzaldehyde | HCID 139901 | — |
| Reactant | Methyl 2-(2-bromophenyl)acetate | HCID 8063364 | — |
| Reactant | Acetone potassium carbonate | HCID 86600397 | — |
| Product | Methyl 2-(4-formyl-2-methylphenoxy)phenylacetate | HCID 19385660 | 96% |
Reaction Steps
Using the K2CO3 /acetone conditions for phenol alkylation described in Step A of Example 30, 0.50 g (3.68 mmol) of 4-hydroxy-3-methylbenzaldehyde was alkylated with 0.926 g (4.05 mmol) of methyl 2-bromophenylacetate to afford 1.00 g (96%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05449682 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-f52b57eac02446f0be03cbd9cf19fbcc |
| Source note | uspto-grants-1995_09 |