反应详情

2.70 g of chloromethanesulfonyl chloride was dropped into a solution of 2.27 g of 2-amino-4,5-diphenylthiazole in pyridine under stirring at room temperature, and the resulting mixture was stirred as such for 2 hours. Then the reaction mixture was poured into ice-water and the crystals thus precipitated were recovered by filtration and separated with a silica gel column by using isopropyl ether and ethyl acetate as a developer. The crystals thus obtained were recrystallized from isopropyl ether/ethyl acetate to give 1.45 g of 2-chloromethanesulfonylamino-4,5-diphenylthiazole. The melting point of this product was from 201° to 203° C.

1. stirringthe resulting mixture was stirred as such for 2 hours
2. customthe crystals thus precipitated
3. filtrationwere recovered by filtration
4. customseparated with a silica gel column
5. customThe crystals thus obtained
6. customwere recrystallized from isopropyl ether/ethyl acetate