2,2,2-Trifluoroethanesulfonyl chloride → HCID 15232781, compound

Participants

Reaction Steps

0.92 g of 2,2,2-trifluoroethanesulfonyl chloride was dropped into a solution of 1:56 g of 2-amino-4,5-bis(4-methoxyphenyl)thiazole in pyridine under stirring at room temperature in a nitrogen atmosphere, and the resulting mixture was stirred as such for 1 hour. Then the reaction mixture was poured into ice-water and the crystals thus precipitated were recovered by filtration and recrystallized from diethyl ether/ethyl acetate to give 0.80 g of 2-(2,2,2-trifluoroethanesulfonyl)amino-4,5-bis(4-methoxyphenyl)thiazole. The melting point of this product was from 259° to 261° C.

Provenance & Evidence