2-Amino-4,5-diphenylthiazole → HCID 15232782, compound

HRID 2399541Notes

Reaction equation

HRID 2399541 reaction equation
[NH2:1][C:2]1[S:3][C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[F:19][C:20]([F:32])([F:31])[C:21]1[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=1>N1C=CC=CC=1>[F:32][C:20]([F:19])([F:31])[C:21]1[CH:22]=[CH:23][C:24]([S:27]([NH:1][C:2]2[S:3][C:4]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[C:5]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:6]=2)(=[O:29])=[O:28])=[CH:25][CH:26]=1

Participants

4

Reactant 2

HCID 732222-Amino-4,5-diphenylthiazoleHCID 27773994-(Trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 15232782HCID 15232782, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.12 g of 2-amino-4,5-diphenylthiazole and 2.44 g of 4-trifluoromethylbenzenesulfonyl chloride were stirred in pyridine at room temperature for 4.5 hours. Then the reaction mixture was poured into ice-water and the crystals thus precipitated were recovered by filtration and recrystallized from isopropyl ether/ethyl acetate to give 0.55 g of 2-(4-trifluoromethylbenzenesulfonyl)amino-4,5-diphenylthiazole. The melting point of this product was from 248° to 249° C.

Workup

  1. customthe crystals thus precipitated
  2. filtrationwere recovered by filtration
  3. customrecrystallized from isopropyl ether/ethyl acetate

Sources & evidence

ORD record
ord-6d1a71d9728145af862403c1e760bfe7
Source dataset
uspto-grants-1995_09
Patent number
US05449783

Reaction notes

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