反应详情

A solution of 4-bromo-2-(p-chlorophenyl)-1-methyl-5-(trifluoromethyl)pyrrole-3-carbonitrile (20.0 g, 0.055 mol) in chlorobenzene at 60° C. is treated with chlorine gas at 60° C. over a 1/2 hour period, cooled to room temperature, washed sequentially with water, aqueous sodium metabisulfite and water, dried over sodium sulfate and concentrated in vacuo to give a residue. The residue is crystallized in heptane to give the title product as a pale yellow solid, 17.6 g (quantitative yield), mp 109.5°-110.5° C.

1. washwashed sequentially with water, aqueous sodium metabisulfite and water
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated in vacuo
4. customto give a residue
5. customThe residue is crystallized in heptane