2-Pyrimidinamine, 4-chloro-6-methoxy- → HCID 19693797, compound

HRID 2399591Notes

Reaction equation

HRID 2399591 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([O:9][CH3:10])[N:3]=1.[CH3:11][O:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([N:21]([C:23]([O:25][CH3:26])=[O:24])[CH3:22])=[CH:17][C:16]=1[S:27]([N:30]=[C:31]=[O:32])(=[O:29])=[O:28])=[O:14].S(=NC(N)=O)(=O)=O>>[Cl:8][C:6]1[CH:5]=[C:4]([O:9][CH3:10])[N:3]=[C:2]([NH:1][C:31]([NH:30][S:27]([C:16]2[CH:17]=[C:18]([N:21]([C:23]([O:25][CH3:26])=[O:24])[CH3:22])[CH:19]=[CH:20][C:15]=2[C:13]([O:12][CH3:11])=[O:14])(=[O:28])=[O:29])=[O:32])[N:7]=1

Participants

4

Reactant 3

HCID 798112-Pyrimidinamine, 4-chloro-6-methoxy-HCID 118190831-SulfonylureaHCID 19693798HCID 19693798, compound

Product 1

HCID 19693797HCID 19693797, compound

Procedure

By analogy with Example m), 0.9 g of 2-amino-4-chloro-6-methoxypyrimidine is reacted with 2.1 g of 2-methoxycarbonyl-5-(N-methoxycarbonyl-N-methylamino)benzenesulfonyl isocyanate (Example 1)). Yield: 0.45 g of the desired sulfonylurea as a solid foam:

Sources & evidence

ORD record
ord-e94053f365c74ba29fae2795305d9dde
Source dataset
uspto-grants-1995_09
Patent number
US05449812

Reaction notes

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