Methanol → HCID 15790214, compound

Participants

Reaction Steps

Potassium hydroxide (0.7 g, 12 mmol) and methanol (2 ml) were stirred together in dimethyl sulfoxide (20 ml) at room temperature for 30 minutes. 4-chloro-1-(2-chloro-4-trifluoromethylphenyl)-pyrrolo[3,2-c]pyridine (2.0 g, 6 mmol) was added and stirring continued for 18 hours. The mixture was poured into water and the precipitate collected by filtration. Further purification by flash column chromatography on silica gel gave 1-(2'-chloro-4'-trifluoromethylphenyl)-4-methoxy-pyrrolo[3,2-c]pyridine (0.35 g) as a pale yellow solid, m.p. 112°-115° C.

Provenance & Evidence