Trimethylsilyl cyanide → HCID 19383044, compound

Participants

Reaction Steps

A solution of 1-(2-chloro-4-trifluoromethylphenyl)-pyrrolo[3,2-c]pyridine 5-oxide (3.5 g, 12 mmol) in triethylamine (50 ml) was cooled in an ice-bath and trimethylsilyl cyanide (10.7 ml, 80 mmol) added dropwise. The ice-bath was removed and the mixture stirred for 5 hours. The precipitate was collected and dried to afford 1-(2-chloro-4-trifluoromethylphenyl)pyrrolo[3,2-c]pyridine (1.8g) as a colorless solid, m.p. 160°-161° C.

Provenance & Evidence