Phosphorus oxychloride → HCID 15790216, compound

Participants

Reaction Steps

4 -chloro-1-(3-chloro-5-trifluoromethylpyridin-2-yl) pyrrolo[3,2-c]pyridine N-oxide (Compound 4, 1.2 g, 3.4 mmol) was heated in phosphorus oxychloride (20 ml) under reflux for 18 hours. The mixture was cooled to room temperature, poured into ice-water, and the mixture made neutral by addition of solid sodium bicarbonate. The resulting mixture was extracted with dichloromethane, and the organic extracts combined, dried over magnesium sulfate, filtered and the filtrate evaporated in vacuo. The residue was further purified by flash column chromatography on silica gel to give 1-(3-chloro-5-trifluoromethylpyridin-2-yl)-4,6-dichloropyrrolo[3,2-c]pyridine (0.24 g) as a colorless oil.

Provenance & Evidence