HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-methyl-2-phenyl-N-prop-2-ynyl-butyramide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | N-methylpropyn-2-ylamine | HCID 96160 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 4-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenylbutanoic acid | HCID 9863428 | — |
| Reactant | N,N-bis(2-oxo-3oxazolidinyl)phosphoramidic chloride | HCID 19975454 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-N-methyl-2-phenyl-N-prop-2-ynyl-butyramide | HCID 9931130 | 93.7% |
Reaction Steps
The title compound was prepared from 4-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylbutanoic acid (1.77 g, 5 mmole), triethylamine (1.518 g, 15 mmole), N,N-bis(2-oxo-3-oxazolidinyl)phosphoramidic chloride (1.527 g, 6 mmole), N-methylpropargylamine (0.415 g, 6 mmole) and methylene chloride (80 mL) in the manner described in Example 1, to yield 1.9 g of the title compound as the dihydrochloride, m.p. 197°-8° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05451584 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-0c3e5acfb8c84853803d0dae23d61440 |
| Source note | uspto-grants-1995_09 |