HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trityl chloride → HCID 54023768, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | rac-(1R,2R)-2-aminocyclopentan-1-ol | HCID 10464306 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54023768 | HCID 54023768 | — |
Reaction Steps
A mixture of trans-2-aminocyclopentanol (45.84 mmol), triphenylmethylchloride (11.50 g; 41.26 mmol) and triethylamine (15.97 ml; 114.60 mmol) in 100 ml CH2Cl2 is refluxed overnight. The reaction mixture is cooled and concentrated in vacuo and flash chromatographed using 5:1; hexane:EtOAc to obtain trans-2-triphenylmethylaminocyclopentanol which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05451596 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-c7e32127b3354af38fc8f8dd93103490 |
| Source note | uspto-grants-1995_09 |