Hydrochloric Acid → HCID 70122073, compound

Participants

Reaction Steps

To a mixture of trans-2-triphenylmethylamino-[4-(benzoxazol-2-yl)benzyloxy]-cyclopentane (3.67 g; 6.67 mmol)in ethanol (100 ml) and CH2Cl2 (20 ml) is added ethanolic HCl until pH≈2. This is stirred overnight, concentrated in vacuo, washed with CH2Cl2, dried under vacuum and flash chromatographed using 3:1; CH2Cl2:EtOH. The product is rechromatographed using 3:1; CH2Cl2 :EtOH to obtain trans-2-amino-[4-(benzoxazol-2-yl)benzyloxy]cyclopentane hydrochloride (m.p. >200° C.).

Provenance & Evidence