Sodium hydride → HCID 19384420, compound

Participants

Reaction Steps

To a mixture of 1-hydroxymethyl-1-triphenylmethylaminocyclopentane (2.95 g; 8.25 mmol) in 100 ml of THF is added sodium hydride (60%; 0.495 g; 12.38 mmol) and allowed to stir for 1 hr. To this mixture is then added 4-(benzoxazol -2-yl)benzyl bromide (1.90 g; 6.60 mmol) and heated to reflux for 48 hrs. The reaction mixture is quenched with H2O, concentrated in vacuo and flash chromatographed using 7:1; hexane:EtOAc to obtain 1-triphenylmethylamino(4-[benzoxazol-2-yl]benzyloxymethyl)cyclopentane which is used directly in the next step.

Provenance & Evidence