Potassium Iodide → HCID 54415333, compound

Participants

Reaction Steps

To a mixture of 2-triphenylmethylaminomethyl-1-hydroxymethylcyclopropane (0.338 g; 0.984 mmol) in 30 ml THF and 5 ml DMF is added sodium hydride (60%; 0.059 g; 1.48 mmol) followed by 4-(benzoxazol-2-yl)benzyl bromide (0.255 g; 0.886 mmol) and a pinch of potassium iodide. This is stirred overnight, quenched with water, concentrated in vacuo and flash chromatographed using hexane:ethyl-acetate; 7:1 to obtain trans-2-triphenylmethylaminomethyl-[4-(benzoxazol-2-yl)-benzyloxymethyl]cyclopropane as a pale yellow oil which is used directly in the next step.

Provenance & Evidence