Hydrochloric Acid → HCID 70123777, compound

Participants

Reaction Steps

To a mixture of trans-2-triphenylmethylaminomethyl-[4-(benzoxazol-2-yl)benzyloxymethyl]cyclopropane (0.252 g; 0.458 mmol) in 40 ml EtOH:CH2Cl2 ; 10:1 is added ethanolic HCl until pH≅2. This is stirred overnight, further ethanolic HCl is added and stirring continued another 24 hrs. The reaction mixture is then heated to reflux for 5 hrs., concentrated in vacuo and flash chromatographed using CH2Cl2 : EtCH; 3:1 to obtain trans-2-aminomethyl-[4-(benzoxazol-2-yl)benzyloxy-methyl]cyclopropane hydrochloride as a white solid (m.p. >250° C.).

Provenance & Evidence