反应详情

温度

50 °C

To a stirred solution of 0.130 g (0.38 mmol) of ethyl-6-[2-(2,6,6-trimethylcyclohex-1-enyl)ethynyl]-2-naphthoate (Compound 3) in 0.7 ml of ethanol was added dropwise under nitrogen 0.9 ml of a 1.86M solution of KOH in ethanol and water. After being stirred at 50 degrees C. for 18 hours, solvent was removed in-vacuo and the residue treated with 1 ml of water and extracted with 1×3 ml portions of ether. The aqueous layer was then acidified with dilute HCl and extracted with 3×3 ml portions of ether. Combined ether extracts were dried (MgSO4), filtered, and concentrated in-vacuo to give the title product.

1. customsolvent was removed in-vacuo
2. additionthe residue treated with 1 ml of water
3. extractionextracted with 1×3 ml portions of ether
4. extractionextracted with 3×3 ml portions of ether
5. dry with materialCombined ether extracts were dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated in-vacuo