Hydrochloric Acid → HCID 19384463, compound

Participants

Reaction Steps

A solution of the methyl ester (0.9 g) from Example 114 in 10 mL of tetrahydrofuran was treated with a solution of 0.8 g of LiOH.H2O in 10 mL water. The reaction mixture was stirred at room temperature for 28 h, diluted with water, acidified with 2N-HCl and extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give 5-[[1,2,3,4-tetrahydro-9-(4-bromophenyl)methyl-9H-dibenzo[b,d]pyrrol-6-yl]oxy]-2-furancarboxylic acid (0.35 g; 40.0%) as a white solid after repeated crystallizations from ethyl acetate, mp 155.5°-157.5° C.

Provenance & Evidence