Monomethyl sulfate → 7-Amino-3-methoxymethyl-3-cephem-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

15.80 g of trimethyl borate were added to 17.9 g of a methanolic solution of methoxysulfonic acid (prepared as described in Preparation 2). The mixture was cooled to -5° C., and 2.74 g of 7-ACA were added thereto, followed by stirring at -5° C. for 5 hours. After completion of the reaction, the reaction mixture was treated following the procedures described in Example 2 to give 2.04 g (yield 83%) of the desired compound in a highly pure form.

Provenance & Evidence