HCID 53785241, compound → HCID 19384996, compound

Participants

Reaction Steps

A solution of 204 mg (0.507 mmol) of Boc amine from Example 16 in methanol was stirred over 20% palladium hydroxide under an atmosphere of hydrogen overnight. The reaction mixture was then filtered and concentrated. Purification by flash chromatography (silica gel, 30% ethyl acetate/hexane) gave 168 mg (82%) of the title compound as a white solid: 1H NMR (200 MHz, CDCl3) δ7.39-7.21 (m, 3H), 7.15-7.06 (m, 4H), 6.96 (d, 2H, J=8.1 Hz), 6.25 (s, 1H), 4.49 (br s, 1H), 3.35-3.24 (m, 4H), 3.18-3.05 (m, 2H), 2.72 (t, 2H, J=7.1 Hz), 1.40 (s, 9H).

Provenance & Evidence