N-[4-(2-aminoethyl)phenyl]Benzenesulfonamide → HCID 44307379, compound

Participants

Reaction Steps

In a manner analogous to that of Example 7, the title compound was prepared from the epoxide from Example 162 and N-[4-(2-aminoethyl)phenyl]benzenesulfonamide (Example 6). Purification by preparative thin layer chromatography on silica gel (eluant 90:10:2 methylen chloride/methanol/30% ammonium hydroxide) gave the title compound. 1H NMR (400 MHz, CD3OD) δ8.23 (d, 1H, J=4Hz), 8.12 (dd, 1H, J=2.4Hz), 7.71(d, 2H, J=8Hz), 7.52 (m, 1H), 7.40-7.48 (m, H), 7.35 (m, 1H), 7.09 (d, 2H, J=10Hz), 7.00 (d, 2H, J=10Hz), 3.95-4.08 (m, 3H), 2.69-2.90 (m, 6H).

Provenance & Evidence