HCID 54413507, compound → HCID 54544963, compound

Participants

Reaction Steps

A solution of 28 mg (0,016 mmol) of the acetamide from Example 208 in 5 mL of methanol and 0.24 mL of 2N aqueous hydrochloric acid was heated at reflux for 3 days. It was then cooled and concentrated. Purification by HPLC (ODS-3, 1:1 methanol:0.1% aqueous trifluoroacetic acid) gave 6.7 mg (13%) the title compound as its bis trifluoracetate salt: 1H NMR (400 MHz, CD3OD) δ8.31 (d, 1H, J=1.5 Hz), 7.96-7.90 (m, 3H), 7.75 (dd, 1H, J=1.9, 8.7 Hz), 7.65-7.57 (m, 2H), 7.11 (s, 4H), 6.89 (s, 2H), 4.12 (m, 1H), 3.89 (dd, 1H, J=5.0, 9.9 Hz), 3.85 (dd, 1H, J=5.3, 9.9 Hz), 3.23-3.11 (m, 4 HO, 2.90-2.86 (m, 2H).

Provenance & Evidence