Aminoisobutyric acid → Methyl 2-aminoisobutyrate hydrochloride

HRID 2399915Notes

Reaction equation

HRID 2399915 reaction equation
[CH3:1][C:2]([CH3:7])([C:4]([OH:6])=[O:5])[NH2:3].[CH3:8][Si]([Cl:12])(C)C>CO>[ClH:12].[CH3:8][O:5][C:4](=[O:6])[C:2]([CH3:7])([CH3:1])[NH2:3]

Participants

4

Reactant 2

HCID 6119Aminoisobutyric acidHCID 6397Chlorotrimethylsilane

Product 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred [solution of 2,2-dimethylglycine (10.0 g, 0.097 mol) in methanol (200 ml) was added trimethylsilyl chloride (37 ml, 0.29 mol). After stirring at room temperature for 14 h. The mixture was evaporated to dryness to give crude 2,2-dimethylglycine methyl ester hydrochloride as a white solid which was used directly in the next step.

Workup

  1. customThe mixture was evaporated to dryness

Sources & evidence

ORD record
ord-13abdd4430944646aadd82588fe5541d
Source dataset
uspto-grants-1995_09
Patent number
US05451676

Reaction notes

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