Benzaldehyde → 2-Methyl-N-(phenylmethylene)-2-propanamine

HRID 2399929노트

반응식

HRID 2399929 반응식
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:9]([NH2:13])([CH3:12])([CH3:11])[CH3:10]>O>[CH:1](=[N:13][C:9]([CH3:12])([CH3:11])[CH3:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 240BenzaldehydeHCID 6385Tert-Butylamine

생성물 1

HCID 1112402-Methyl-N-(phenylmethylene)-2-propanamine수율 88.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a three neck round bottom flask, equipped with a cold water condenser, 30 g of water and 26.5 g of benzaldehyde were added. The mixture was mixed with a magnetic stirrer at room temperature for 3 minutes. t-Butyl amine (22.1 g) was added to the reaction flask in one portion, followed by vigorous stirring for 15 hours. The agitation was stopped and the reaction mixture was allowed to stand for at least 15 minutes. The lower aqueous layer was separated from the reaction mixture. The upper layer was collected and dried over magnesium sulfate to give 35.5 g of product. 1H NMR (300 Hz, CDCl3, ppm): 8.29 (1H, s), 7.77 (2H, m), 7.40 (3H, m), 1.33 (9H, s).

후처리

  1. customTo a three neck round bottom flask, equipped with a cold water condenser
  2. additionThe mixture was mixed with a magnetic stirrer at room temperature for 3 minutes
  3. waitto stand for at least 15 minutes
  4. customThe lower aqueous layer was separated from the reaction mixture
  5. customThe upper layer was collected
  6. dry with materialdried over magnesium sulfate

출처 및 근거

ORD 기록
ord-29f50643f535465cab600c3c04e42f1e
출처 데이터셋
uspto-grants-1995_09
특허 번호
US05451653

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