反应详情

To a three neck round bottom flask, equipped with a cold water condenser, 30 g of water and 26.5 g of benzaldehyde were added. The mixture was mixed with a magnetic stirrer at room temperature for 3 minutes. t-Butyl amine (22.1 g) was added to the reaction flask in one portion, followed by vigorous stirring for 15 hours. The agitation was stopped and the reaction mixture was allowed to stand for at least 15 minutes. The lower aqueous layer was separated from the reaction mixture. The upper layer was collected and dried over magnesium sulfate to give 35.5 g of product. 1H NMR (300 Hz, CDCl3, ppm): 8.29 (1H, s), 7.77 (2H, m), 7.40 (3H, m), 1.33 (9H, s).

1. customTo a three neck round bottom flask, equipped with a cold water condenser
2. additionThe mixture was mixed with a magnetic stirrer at room temperature for 3 minutes
3. waitto stand for at least 15 minutes
4. customThe lower aqueous layer was separated from the reaction mixture
5. customThe upper layer was collected
6. dry with materialdried over magnesium sulfate