反应详情

A solution of the ester (35) (0.15 g, 0.222 mmol) in dry benzene (3 ml) under nitrogen was treated with a catalytic amount of toluenesuphonic acid and the resulting solution heated at reflux for 5 hours, after which time no starting material remained on tlc. The volatile components were removed in vacuo and the residue chromatographed on silica (5 g). Elution with 10% ether in petrol gave the title compound (42) as a white wax (0.1 g, 73%).

1. temperaturethe resulting solution heated
2. temperatureat reflux for 5 hours
3. customThe volatile components were removed in vacuo
4. customthe residue chromatographed on silica (5 g)
5. washElution with 10% ether in petrol