HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → N-Boc-L-serine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | N-[tert-butoxycarbonyl]-L-serine | HCID 98766 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-Boc-L-serine methyl ester | HCID 7019177 | 90% |
Reaction Steps
A solution of the acid (23) in ether (200 ml) at room temperature was treated with ethereal diazomethane until the yellow colour just persisted and tlc showed there to be no starting material present. The volatiles were then removed in vacuo leaving the product (24) as a light orange oil (17.89 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05451691 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-3389b9e0c13341b994f843b5358dc123 |
| Source note | uspto-grants-1995_09 |