Potassium Carbonate → (3aRS, 7aRS)-2-benzyl-7,7-diphenyl-4-perhydroisoindolone

Participants

Reaction Conditions

Reaction Steps

5 drops of trifluoroacetic acid are added to a solution of 155 g of 4,4-diphenyl-2-cyclohexen-1-one and 202 cm3 of N-butoxymethyl-N-trimethylsilylmethylbenzylamine in 1000 cm3 of dry dichloromethane and the reaction mixture is refluxed for 45 minutes. 50 cm3 of N-butoxy-methyl-N-trimethylsilylmethylbenzylamine and 3 drops of trifluoroacetic acid are added and the mixture is further stirred for 45 minutes under reflux before again adding 25 cm3 of N-butoxymethyl-N-trimethylsilyl-methylbenzylamine and 3 drops of trifluoroacetic acid. The reaction mixture is stirred under reflux for 45 minutes and then treated with 50 g of potassium carbonate, filtered and concentrated to dryness under reduced pressure (2.7 kPa). The residue is dissolved in 200 cm3 of isopropyl oxide and the solution is cooled at 0° C. for 1 hour. The crystals are drained, washed twice with 15 cm3 of isopropyl oxide and dried to give 193 g of (3aRS,7 aRS)-2-benzyl-7,7-diphenyl-4-perhydroisoindolone in the form of white crystals; melting point 132° C.

Provenance & Evidence