HCID 54240179, compound → HCID 22856109, compound

HRID 2400019Notes

Reaction equation

[OH:1][CH2:2][CH2:3][N:4]([CH2:6][CH:7]([O:9][CH:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:11]([OH:13])=O)[CH3:8])[CH3:5].Cl.[C:21]1([C:27]2([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[CH2:35][CH2:34][C@@H:33]([F:36])[C@@H:32]3[C@H:28]2[CH2:29][NH:30][CH2:31]3)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[OH:1][CH2:2][CH2:3][N:4]([CH2:6][CH:7]([O:9][CH:10]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:11]([N:30]1[CH2:29][C@@H:28]2[C@@H:32]([C@H:33]([F:36])[CH2:34][CH2:35][C:27]2([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH2:31]1)=[O:13])[CH3:8])[CH3:5]

Participants

Reactant 2

HCID 54240179HCID 54240179, compound

HCID 67746156(3aR, 7R,7aR)-4,4-diphenyl-7-fluoroperhydroisoindole hydrochloride

Product 1

HCID 22856109HCID 22856109, compoundYield 43.7%

Procedure

By carrying out the procedure as in Example 2, but using 1.37 g of {3-[N-(2-hydroxyethyl)-N-methylamino]-2-propoxy}phenylacetic acid and 1.2 g of (3aR, 7R, 7aR)-4,4-diphenyl-7-fluoroperhydroisoindole hydrochloride, 0.86 g of (3aR,7R,7aR)-2-{{3-[N-(2-hydroxyethyl)-N-methylamino]-2-propoxy}phenylacetyl}-4,4-diphenyl-7-fluoroperhydroisoindole is obtained, after purification by chromatography on a silica gel column, in the form of a white meringue.

Sources & evidence

ORD record: ord-f17dfb72c2c94cbdacbd7733f313c53f
Source dataset: uspto-grants-1995_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05451601

Reaction notes

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