9H-Fluoren-9-ylideneacetic acid → HCID 22856181, compound

HRID 2400036Notes

Reaction equation

HRID 2400036 reaction equation
[NH2:1][C@@H:2]1[C:7]2[CH:8]=[C:9]([C:12]#[N:13])[CH:10]=[CH:11][C:6]=2[O:5][C:4]([CH3:15])([CH3:14])[C@H:3]1[OH:16].[CH:17]1[C:29]2[C:28](=[CH:30][C:31](O)=[O:32])[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:21]=2[CH:20]=[CH:19][CH:18]=1>>[C:12]([C:9]1[CH:10]=[CH:11][C:6]2[O:5][C:4]([CH3:14])([CH3:15])[C@@H:3]([OH:16])[C@H:2]([NH:1][C:31](=[O:32])[CH:30]=[C:28]3[C:29]4[CH:17]=[CH:18][CH:19]=[CH:20][C:21]=4[C:22]4[C:27]3=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:7]=2[CH:8]=1)#[N:13]

Participants

3

Reactant 2

HCID 967929H-Fluoren-9-ylideneacetic acidHCID 10943936(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile

Product 1

HCID 22856181HCID 22856181, compound

Procedure

The title compound was prepared from (3S-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (the title B compound of Example 1) and 2-(9H-fluoren-9-ylidene)acetic acid by the same method as described for the title compound of Example 2. The product was obtained as a light yellow solid, m.p. >300° C.

Workup

  1. customThe product was obtained as a light yellow solid, m.p. >300° C.

Sources & evidence

ORD record
ord-e874093d480e45a79a60e9c3fb995703
Source dataset
uspto-grants-1995_09
Patent number
US05453421

Reaction notes

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