(3S,4R)-4-amino-3-hydroxy-2,2-dimethyl-chroman-6-carbonitrile → HCID 88437089, compound

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Reaction Steps

The title compound was prepared from (3S-trans)-4-amino-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (the title B compound of Example 1) and 1-(3-ethynylphenyl)-5-phenyl-1,2,3-triazole-5-carboylic acid by the same method as described for the title compound of Example 2 to afford a white solid, m.p. 115°-125° C. (softens at 81° C.). [α]D =-110.1° (c=0.69, MeOH).

Provenance & Evidence