Sodium Chloride → HCID 19382363, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-2-benzoylfuran (4.93 g, 0.025 mol) was dissolved in s dry methylene chloride (50 mL). The solution was cooled to 0° C. under nitrogen and triethylamine (3.8 mL, 0.0275 mol) was added followed by bromoacetyl bromide (2.4 mL, 0.0275 mol). The mixture was stirred at 0° C. for five hours. Next another 10% of triethylamine and bromoacetyl bromide were added and the reaction was left over night. Ehtyl acetate (200 mL) and saturated NaCl (75 mL) were added. The ethyl acetate layer was separated, washed with saturated NaCl solution, dried over sodium sulfate, filtered and concentrated in vacuo. A tan solid was obtained in theoretical yield (7.7 g).

Provenance & Evidence