HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-(aminomethyl)-1-benzylpyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-Benzyl-1-oxa-5-azaspiro[2.4]heptane | HCID 11194805 | — |
| Product | 3-(aminomethyl)-1-benzylpyrrolidin-3-ol | HCID 14578451 | — |
Reaction Steps
9.7 g (51.3 mmol) of 5-benzyl-5-aza-1-oxaspiro[2,4]heptane (U.S. Pat. No. 4,508,724) are added dropwise to 50 ml of ammonia solution (25%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05453422 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-1f4f1abbed564489a27aab0dbe8095ba |
| Source note | uspto-grants-1995_09 |