HCID 19382170, compound → HCID 19382210, compound

HRID 2400062Notes

Reaction equation

HRID 2400062 reaction equation
[ClH:1].Cl.C([N:10]1[CH2:14][CH2:13][C:12]([OH:18])([CH2:15][NH:16][CH3:17])[CH2:11]1)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[OH:18][C:12]1([CH2:15][NH:16][CH3:17])[CH2:13][CH2:14][NH:10][CH2:11]1

Participants

4

Reactant 1

HCID 19382170HCID 19382170, compound

Product 1

HCID 19382210HCID 19382210, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

6.9 g (23.5 mmol) of 1-benzyl-3-hydroxy-3-methylaminomethylpyrrolidine dihydrochloride in 100 ml of methanol are hydrogenated on 2 g of palladium/active carbon (10%) at 80°C. and 100 bar. The catalyst is filtered off with suction, the solution is concentrated and the residue is triturated with butanol. The crystalline salt is filtered off with suction, washed with acetone and dried.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe solution is concentrated
  3. customthe residue is triturated with butanol
  4. filtrationThe crystalline salt is filtered off with suction
  5. washwashed with acetone
  6. customdried

Sources & evidence

ORD record
ord-889528d95ea2424a9711847a2df4c179
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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