HCID 19382175, compound → HCID 19382179, compound

HRID 2400063Notes

Reaction equation

HRID 2400063 reaction equation
[ClH:1].Cl.C([N:10]1[CH2:14][CH2:13][C:12]([CH2:16][NH:17][CH:18]2[CH2:20][CH2:19]2)([OH:15])[CH2:11]1)C1C=CC=CC=1>CO.[Pd]>[ClH:1].[ClH:1].[CH:18]1([NH:17][CH2:16][C:12]2([OH:15])[CH2:13][CH2:14][NH:10][CH2:11]2)[CH2:20][CH2:19]1

Participants

4

Reactant 1

HCID 19382175HCID 19382175, compound

Product 1

HCID 19382179HCID 19382179, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.9 g (24.7 mmol) of 1-benzyl-3-cyclopropylaminomethyl-3-hydroxypyrrolidine dihydrochloride in 100 ml of methanol are hydrogenated on 2 g of palladium/active carbon (10%) at 50° C. and 100 bar. The product is filtered off with suction and concentrated, and the residue is triturated with butanol. The crystalline salt is filtered off with suction, washed with acetone and dried.

Workup

  1. filtrationThe product is filtered off with suction
  2. concentrationconcentrated
  3. customthe residue is triturated with butanol
  4. filtrationThe crystalline salt is filtered off with suction
  5. washwashed with acetone
  6. customdried

Sources & evidence

ORD record
ord-504aa8bd23eb488f8f836d2e8ebddb7f
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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