Ammonia → HCID 14578460, compound

HRID 2400064Notes

Reaction equation

HRID 2400064 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][CH3:12])=[O:10])[CH2:4]2)[CH2:2]1.[NH3:13]>>[NH2:13][CH2:2][C:3]1([OH:1])[CH2:8][CH2:7][CH2:6][N:5]([C:9]([O:11][CH3:12])=[O:10])[CH2:4]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19382148HCID 19382148, compound

Product 1

HCID 14578460HCID 14578460, compound

Procedure

9.1 g (53.2 mmol) of methyl 5-aza-1-oxaspiro[2,5]octane-5-carboxylate are added dropwise to 50 ml of ammonia solution (25%) and the mixture is stirred overnight at room temperature. It is then concentrated and the residue is distilled.

Workup

  1. concentrationIt is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-7d10fe5a5b4646018bda1c170db73ef9
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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