Dimethylamine → 3-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

HRID 2400078Notes

Reaction equation

HRID 2400078 reaction equation
[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]2([O:12][CH2:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:15][NH:16][CH3:17]>>[CH2:1]([N:8]1[CH2:14][CH2:13][C:10]([CH2:11][N:16]([CH3:17])[CH3:15])([OH:12])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 674DimethylamineHCID 111948055-Benzyl-1-oxa-5-azaspiro[2.4]heptane

Product 1

HCID 145784553-[(Dimethylamino)methyl]-1-(phenylmethyl)-3-pyrrolidinol

Procedure

9.6 g (50 mmol) of 5-benzyl-5-aza-1-oxaspiro[2,4]heptane are added dropwise to 50 ml of dimethylamine solution (50%) and the mixture is stirred overnight at room temperature. The batch is then concentrated and the residue is distilled.

Workup

  1. concentrationThe batch is then concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-61bd4c3f42f946ddafe7d895b4c39833
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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