1,1-Dimethylethyl N-[[3-hydroxy-1-(phenylmethyl)-3-pyrrolidinyl]methyl]carbamate → 3-(Boc-aMinoMethyl)-3-hydroxypyrrolidine

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Reaction Steps

18.7 g (61 mmol) of 1-benzyl-3-tert.-butoxycarbonylaminomethyl-3-hydroxypyrrolidine are dissolved in 120 ml of methanol and hydrogenated on 3 g of 5% strength Pd/active carbon at 90° C. and 100 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is recrystallized from ethyl acetate.

Provenance & Evidence