HCID 19382157, compound → 3-Aminomethyl-1-benzyl-3-methoxy-pyrrolidine

HRID 2400088Notes

Reaction equation

HRID 2400088 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][C:10]([C:15]#[N:16])([O:13][CH3:14])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[Ni]>[NH2:16][CH2:15][C:10]1([O:13][CH3:14])[CH2:11][CH2:12][N:8]([CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:9]1

Participants

3

Reactant 1

HCID 19382157HCID 19382157, compound

Product 1

HCID 537457403-Aminomethyl-1-benzyl-3-methoxy-pyrrolidine

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The solution of 26.5 g (0.11 mol, 93% proof) 1-benzyl-3-cyano-3-methoxypyrrolidine in 300 ml methanole is hydrogenated at 15 g Raney-Ni at 60° C./100 bar H2. The catalyst is removed by filtration, the methanol is removed in vacuo, and the residue is destilled.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe methanol is removed in vacuo

Sources & evidence

ORD record
ord-78f68eadc00b4b53aff93a287d1eb715
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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