HCID 19382222, compound → HCID 22924380, compound

HRID 2400089Notes

Reaction equation

HRID 2400089 reaction equation
C([N:8]1[CH2:12][CH2:11][C:10]([CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])([O:13][CH3:14])[CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd].[C]>[C:20]([O:19][C:17]([NH:16][CH2:15][C:10]1([O:13][CH3:14])[CH2:11][CH2:12][NH:8][CH2:9]1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 1

HCID 19382222HCID 19382222, compound

Product 1

HCID 22924380HCID 22924380, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

12 g (37.4 mmol) 1-benzyl-3-(tert.-butoxy-carbonylamino-methyl)-3-methoxypyrrolidine is desolved in 150 ml ethanol. This solution is hydrogeneted at 4 g Pd-carbon (10 %) at 100° C./100 bar H2. The catalyst is removed by filtration, and the organic solvents are removed in vacuo. The residue is destilled.

Workup

  1. customThe catalyst is removed by filtration
  2. customthe organic solvents are removed in vacuo

Sources & evidence

ORD record
ord-fc4210686d5f40e7b5e97e249c9c0a55
Source dataset
uspto-grants-1995_09
Patent number
US05453422

Reaction notes

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