2,2-Dimethyl-1,3-dioxane-4,6-dione → 8-Hydroxy-3-carboxy-coumarin

Participants

Reaction Conditions

Reaction Steps

2,3-dihydroxybenzaldehyde (0.096 g, 0.69 mmol) and Meldrum's acid (0.100 g, 0.69 mmol) were combined in H2O (1 mL). The solution was stirred at 75° C. for 2 h. After cooling to room temperature, the precipitate was filtered and dried at suction to give 0.123 g of 8-hydroxy-3-carboxy-coumarin in an 85% yield: LCMS (ESI) m/z 207 (MH+).

Provenance & Evidence