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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2400091Generated: November 1, 2026

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-hydroxy-4-methylaminomethyl-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid

https://huagongshe.com/reaction/2400091

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 5210422—
Reactant4-Hydroxy-4-methylaminomethylpiperidine dihydrochlorideHCID 19382178—
Product1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(4-hydroxy-4-methylaminomethyl-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acidHCID 14578485—

Reaction Steps

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is reacted with 4-hydroxy-4-methylaminomethylpiperidine dihydrochloride analogously to Example 6 to give 1-cyclopropyl-6-fluoro-1,4-dihydro-7-(4-hydroxy-4-methylaminomethyl-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid of melting point 162° (with decomposition).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05453422
Source datasetuspto-grants-1995_09
ORD IDord-8297bc6561ba4ee29393160e76cb1c84
Source noteuspto-grants-1995_09