Sulfuric Acid → HCID 135837533, compound

HRID 2400098Notes

Reaction equation

HRID 2400098 reaction equation
[Br:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6](Br)[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.S(=O)(=O)(O)[OH:18]>O>[Br:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:5][C:6](=[O:18])[C:7]=1[CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 196907014,6-Dibromo-5-ethyl-2-phenylpyrimidine

Product 1

HCID 135837533HCID 135837533, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 8.29 g (26.1 mmol) of crude 4,6-dibromo-5-ethyl-2-phenylpyrimidine was added a mixture of 4 mL of water and 15 mL of concentrated sulfuric acid. The mixture was stirred for 18 h and poured onto 200 g of crushed ice. After the ice had melted the precipitate was collected by filtration and dried under vacuum to afford 7.21 g (99%) of crude 6-bromo-5-ethyl-2-phenyl-4(3H)-pyrimidinone. 1H-NMR (d6 -DMSO)δ1.10(3H,t), 2.55(2H,q), 7.55(3H, m), 8.10(2H,m).

Workup

  1. filtrationwas collected by filtration
  2. customdried under vacuum

Sources & evidence

ORD record
ord-c5e52ba689d240e6809bc3cf1b285f18
Source dataset
uspto-grants-1995_09
Patent number
US05453414

Reaction notes

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