HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenol → HCID 19044668, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (6-Chloro-2-methyl-5-pyrimidyl)acetic acid, ethyl ester | HCID 26604 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19044668 | HCID 19044668 | — |
Reaction Steps
Ethyl α-(2-methyl-4-chloro-5-pyrimidinyl)-acetate (3 g, 14 mmol), 3-trifluoromethyl phenol (3 g, 14 mmol) and potassium carbonate (11 g, 80 mmol) in dimethylformamide (50 ml) are stirred at +80° C. for 3 hours. The mixture is diluted with ether and washed with brine. Drying over MgSO4 and evaporation of the solvent gives pure ethyl α-[2-methyl-4-(3-trifluoromethylphenoxy)-5-pyrimidinyl]acetate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05453427 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-cf2b357c89bc4f039a214ba864a9755e |
| Source note | uspto-grants-1995_09 |