HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate → Methyl [6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl alpha-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate | HCID 19044661 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Triethylamine methanol | HCID 22728368 | — |
| Product | Methyl [6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate | HCID 19044665 | — |
Reaction Steps
Methyl α-[6-methyl-2-chloro-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate is dissolved in methanol/triethylamine (50 ml/10 ml) and hydrogenated over Pd on charcoal (0.2 g). The reaction mixture is evaporated. Addition of potassium carbonate, ether extraction and chromatography on silica gel gives pure methyl α-[6-methyl-4-(3-phenylphenoxy)-5-pyrimidinyl]-acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05453427 |
| Source dataset | uspto-grants-1995_09 |
| ORD ID | ord-8c5651326c36428e8fcef44f6cfc5f83 |
| Source note | uspto-grants-1995_09 |